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Sigma-Aldrich

Resomer® RG 505, Poly(D,L-lactide-co-glycolide)

ester terminated, Mw 54,000-69,000

Synonym(e):

PLGA

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About This Item

Lineare Formel:
[C3H4O2]x[C2H2O2]y
CAS-Nummer:
26780-50-7
UNSPSC-Code:
12162002
NACRES:
NA.23

Form

amorphous

Zufuhrverhältnis

lactide:glycolide 50:50

Mol-Gew.

Mw 54,000-69,000

Zeitrahmen für den Abbau

<3 months

Viskosität

0.61-0.74 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

Übergangstemp.

Tg 48-52 °C

Lagertemp.

2-8°C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChIKey

LCSKNASZPVZHEG-UHFFFAOYSA-N

Verwandte Kategorien

Allgemeine Beschreibung

Poly(lactide-co-glycolide)(PLGA) is a biodegradable polymer used in the preparation of polymericmicrospheres. These polymers degrade in vivo by hydrolysis of their esterbackbone into non-toxic products, which are excreted by the kidneys oreliminated as CO2 and water through biochemical pathways. PLGAmicrospheres have been widely used to encapsulate drug molecules and have beenused as long-acting, sustained-release pharmaceutical formulations.

Anwendung

Poly(lactide-co-glycolide)(PLGA) can be used to fabricate sustained-release drug delivery systems, for example, it can be used to encapsulate the anti-inflammatory lipophilic drug atorvastatin.

Rechtliche Hinweise

Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging
Igor Jeroukhimov et al.
Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)
Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures
Hannu Paajanen et al.
International journal of surgery (London, England), 11(1), 81-84 (2012-12-19)
Chronic pain may be a major long-term problem related to mesh material and operative trauma in inguinal hernioplasty. Lichtenstein hernioplasty was performed under local anaesthesia in 312 patients by the same surgeon and technique between 2003 and 2005. The patients
Kyle E Broaders et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(14), 5497-5502 (2009-03-27)
Materials that combine facile synthesis, simple tuning of degradation rate, processability, and biocompatibility are in high demand for use in biomedical applications. We report on acetalated dextran, a biocompatible material that can be formed into microparticles with degradation rates that
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Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.

Poly(Glycerol Sebacate) in Tissue Engineering

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

Biodegradable Polyester Nanoparticle Formation

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation

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