651753

2-Chlor-5-Fluorpyrimidin

97%

• Empirische Formel (Hill-System): C₄H₂ClFN₂
• CAS-Nummer: 62802-42-0
• Molekulargewicht: 132.52
• MDL-Nummer: MFCD03788197
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24883860
• NACRES: NA.22

Eigenschaften

• Assay: 97%
• Brechungsindex: n20/D 1.503 (lit.)
• Dichte: 1.439 g/mL at 20 °C (lit.)
• Funktionelle Gruppe: chloro; fluoro
• SMILES String: Fc1cnc(Cl)nc1
• InChI: 1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H
• InChIKey: AGYUQBNABXVWMS-UHFFFAOYSA-N

Beschreibung

Anwendung

2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:

• 5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K₂CO₃, via C-N bond forming reaction.
• 2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.
• 5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H302,H314
• P-Sätze: P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Gefahreneinstufungen: Acute Tox. 4 Oral - Skin Corr. 1B
• Lagerklassenschlüssel: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): 149.0 °F - closed cup
• Flammpunkt (°C): 65 °C - closed cup
• Persönliche Schutzausrüstung: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter