362433

Diethyl(N-methoxy-N-methylcarbamoylmethyl)phosphonat

96%

• Synonym(e): N-Methoxy-N-methylphosphonsäureacetamid-diethylester, Diethyl-N-methoxy-N-methylphosphonsäure-acetamid
• Lineare Formel: CH₃ON(CH₃)COCH₂P(O)(OC₂H₅)₂
• CAS-Nummer: 124931-12-0
• Molekulargewicht: 239.21
• Beilstein: 1875865
• MDL-Nummer: MFCD00134233
• UNSPSC-Code: 12352108
• PubChem Substanz-ID: 24862312
• NACRES: NA.22

Eigenschaften

• Assay: 96%
• Form: liquid
• Eignung der Reaktion: reaction type: C-C Bond Formation
• Brechungsindex: n20/D 1.455 (lit.)
• bp: 90 °C/17 mmHg (lit.)
• Dichte: 1.163 g/mL at 25 °C (lit.)
• Funktionelle Gruppe: amine; phosphonate
• SMILES String: CCOP(=O)(CC(=O)N(C)OC)OCC
• InChI: 1S/C8H18NO5P/c1-5-13-15(11,14-6-2)7-8(10)9(3)12-4/h5-7H2,1-4H3
• InChIKey: WYLRYBDGIILFIR-UHFFFAOYSA-N

Beschreibung

Anwendung

Wittig carbonylating reagent.

Reactant for:

• Preparation of ring-expanded bryostatin analogs as antitumor agents
• Asymmertic synthesis of pinnatoxins A and G via diastereoselective Ireland-Claisen rearrangement, ring closing metathesis, and cyclization
• Rh2(II)-catalyzed nitro-group migration reactions
• Stereoselective synthesis of cyclohexanones via phase transfer catalyzed double addition reactions
• Stereoselective synthesis of (+)-polyrhacitide A via aldol reaction, Horner-Wardsworth-Emmons reaction, Evans acetal intramolecular oxa-Michael reaction and diastereoselective syn reduction reaction as the key steps
• Preparation of substituted furans via olefin cross-metathesis

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): 230.0 °F - closed cup
• Flammpunkt (°C): 110 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type ABEK (EN14387) respirator filter