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Dokumente

335665

Sigma-Aldrich

7-Hydroxycumarinyl-4-essigsäure

97%

Synonym(e):

Umbelliferon-4-essigsäure

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About This Item

Empirische Formel (Hill-System):
C11H8O5
CAS-Nummer:
6950-82-9
Molekulargewicht:
220.18
Beilstein:
204777
MDL-Nummer:
MFCD00037563
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24860338
NACRES:
NA.22

Assay

97%

Form

powder

mp (Schmelzpunkt)

212 °C (dec.) (lit.)

SMILES String

OC(=O)CC1=CC(=O)Oc2cc(O)ccc12

InChI

1S/C11H8O5/c12-7-1-2-8-6(3-10(13)14)4-11(15)16-9(8)5-7/h1-2,4-5,12H,3H2,(H,13,14)

InChIKey

BNHPMQBVNXMPDU-UHFFFAOYSA-N

Anwendung

7-Hydroxycoumarinyl-4-acetic acid was used in the synthesis of novel and specific enzyme substrates for Maroteaux-Lamy (MPS VI) and Morquio A (MPS IVA) diseases. It was also employed as ionic liquid matrice for MALDI-TOF MS of proteins, peptides and carbohydrates.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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7-(Diethylamino)cumarin-3-carbonsäure BioReagent, suitable for fluorescence, ≥98.0% (HPCE)

Sigma-Aldrich

36799

7-(Diethylamino)cumarin-3-carbonsäure

Erland J F Demant et al.
The Biochemical journal, 363(Pt 3), 809-815 (2002-04-20)
The kinetics of the interaction of long-chain fatty acids (referred to as fatty acids) with albumin is critical to understanding the role of albumin in fatty acid transport. In this study we have determined the kinetics of fatty acid dissociation
E J Demant et al.
Analytical biochemistry, 295(1), 38-44 (2001-07-31)
The fluorescence-based long-chain fatty acid probe BSA-HCA (bovine serum albumin labeled with 7-hydroxycoumarin-4-acetic acid) is shown to respond to binding of long-chain acyl-CoA thioesters by quenching of the 450 nm fluorescence emission. As determined by spectrofluorometric titration, binding affinities for
Trisha A Duffey et al.
Bioorganic & medicinal chemistry letters, 20(20), 5994-5996 (2010-09-14)
In continued efforts to develop enzymatic assays for lysosomal storage diseases appropriate for newborn screening laboratories we have synthesized novel and specific enzyme substrates for Maroteaux-Lamy (MPS VI) and Morquio A (MPS IVA) diseases. The sulfated monosaccharide derivatives were found
Yan Chen et al.
Analytical biochemistry, 540-541, 38-44 (2017-11-13)
To establish a high throughput, low cost, and simple nanotechnology-based method for the detection of single nucleotide polymorphism (SNP) loci in type 2 diabetes mellitus (T2DM). Multiplex ligase detection reaction (LDR) amplification was performed using fluorescently labeled magnetic nanosphere-bound upstream
E J Demant
Analytical biochemistry, 267(2), 366-372 (1999-02-26)
A covalent complex between bovine serum albumin and 7-hydroxycoumarin-4-acetic acid (BSA-HCA) shows a strong fluorescence band at lambdamax = 450 nm upon excitation at 375 nm. Quenching of the fluorescence emission accompanies the association of fatty acids (FA) to BSA-HCA
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