285773

α-Oestradiol

98%

• Synonym(e): α-Estradiol, 1,3,5(10)-Estratrien-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratrien, Epiestradiol
• Empirische Formel (Hill-System): C₁₈H₂₄O₂
• CAS-Nummer: 57-91-0
• Molekulargewicht: 272.38
• MDL-Nummer: MFCD00064144
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329753246

Eigenschaften

• Assay: 98%
• Verunreinigungen: <3% water
• SMILES String: [H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
• InChIKey: VOXZDWNPVJITMN-SFFUCWETSA-N

Beschreibung

Biochem./physiol. Wirkung

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.