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275778

Sigma-Aldrich

Imidazo[1,2-a]pyridin

99%

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About This Item

Empirische Formel (Hill-System):
C7H6N2
CAS-Nummer:
274-76-0
Molekulargewicht:
118.14
MDL-Nummer:
MFCD00005553
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24856670
NACRES:
NA.22

Assay

99%

Form

liquid

Brechungsindex

n20/D 1.626 (lit.)

bp

103 °C/1 mmHg (lit.)

Dichte

1.165 g/mL at 25 °C (lit.)

SMILES String

c1ccn2ccnc2c1

InChI

1S/C7H6N2/c1-2-5-9-6-4-8-7(9)3-1/h1-6H

InChIKey

UTCSSFWDNNEEBH-UHFFFAOYSA-N

Verwandte Kategorien

Allgemeine Beschreibung

In vivo anti-trypanosomal activity of imidazo[1,2-a]pyridiness in the STIB900 mouse model has been investigated.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

235.4 °F - closed cup

Flammpunkt (°C)

113 °C - closed cup

Persönliche Schutzausrüstung

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Analysenzertifikate (COA)

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7-Azaindol 98%

Sigma-Aldrich

A95502

7-Azaindol

Benzimidazol 98%

Sigma-Aldrich

194123

Benzimidazol

2-Aminopyridin ≥99%

Sigma-Aldrich

A77989

2-Aminopyridin

Garrett C Moraski et al.
Bioorganic & medicinal chemistry, 20(7), 2214-2220 (2012-03-07)
Tuberculosis (TB) is a devastating disease resulting in a death every 20s. Thus, new drugs are urgently needed. Herein we report ten classes of compounds-oxazoline, oxazole, thiazoline, thiazole, pyrazole, pyridine, isoxazole, imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine and imidazo[1,2-c]pyrimidine-which have good (micromolar) to excellent
Richard Ducray et al.
Bioorganic & medicinal chemistry letters, 21(16), 4702-4704 (2011-07-19)
Following the discovery of imidazopyridine 1 as a potent IGF-1R tyrosine kinase inhibitor, the aniline part has been modified with the aim to optimize the properties of this series. The structure-activity relationships against IGF-1R kinase activity as well as inhibition
Suren Husinec et al.
Organic letters, 13(9), 2286-2289 (2011-03-31)
A base promoted cyclization of the protected N-propargylaminopyridines was shown to be an efficient method for the preparation of imidazo[1,2-a]pyridine derivatives. The reactions were carried out with a small excess of base, at room temperature or slightly above producing the
Mohamed A Ismail et al.
Bioorganic & medicinal chemistry, 16(2), 683-691 (2007-11-03)
The key dinitrile intermediates 4a-d were synthesized by reaction of phenacyl bromide 1 and the appropriate 2-amino-5-bromopyridines to yield 3a-d. Suzuki coupling of 3a-d with 4-cyanophenylboronic acid yielded the 2,6-bis(4-cyanophenyl)-imidazo[1,2-a]pyridine derivatives 4a-d. The bis-amidoximes 5a-d, obtained from 4a-d by the
Hongpeng Sun et al.
The Journal of organic chemistry, 77(23), 10745-10751 (2012-11-22)
An efficient tandem route to the synthesis of 3H-1,2a(1),3-triazaacenaphthylene derivatives of the cyclazine family has been developed. Target compounds were obtained in moderate to good yields by a Yb(OTf)(3)/Ag(2)CO(3)-catalyzed, three-component domino reaction. This in turn will set the stage for
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