SCN1A
sodium channel, voltage-gated, type I, alpha subunit
Synonyme:
EIEE6, FEB3, FEB3A, FHM3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SMEI
Spezies:
Human SCN1A (6323), Mouse Scn1a (20265), Rat Scn1a (81574), domestic guinea pig Scn1a (100715839), chicken SCN1A (771555), naked mole-rat Scn1a (101710495), Zebrafish scn1a (100536219), Zebrafish scn1a (393101), cow SCN1A (529590), dog SCN1A (478775) ...Mehr
UniProtKB-ID:
Gen-ID:
- Human(6323) Summary: The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.[provided by RefSeq, Jan 2011]
- Mouse(20265) sodium channel, voltage-gated, type I, alpha
- Rat(81574) sodium channel, voltage-gated, type I, alpha
- domestic guinea pig(100715839) sodium channel, voltage-gated, type I, alpha subunit
- chicken(771555) sodium channel, voltage-gated, type I, alpha subunit
- naked mole-rat(101710495) sodium channel, voltage-gated, type I, alpha subunit
- Zebrafish(100536219) sodium channel, voltage-gated, type I, alpha subunit
- Zebrafish(393101) sodium channel, voltage-gated, type I, alpha
- cow(529590) sodium channel, voltage-gated, type I, alpha subunit
- dog(478775) sodium channel, voltage-gated, type I, alpha subunit
- Horse(100052059) sodium channel, voltage-gated, type I, alpha subunit
- sheep(101123531) sodium channel, voltage-gated, type I, alpha subunit
- domestic cat(101081823) sodium channel, voltage-gated, type I, alpha subunit
- Domestic Rabbit(100009591) sodium channel, voltage-gated, type I, alpha subunit
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Small Molecule - Antagonist
Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Natriumkanal-Antikörper, spannungsgesteuert, Gehirn Typ I, Chemicon®, from rabbit,
Speziesreaktivität
mouse, rat
Anwendung
immunohistochemistry
western blot
western blot
Anti-Sodium Channel, Pan antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Speziesreaktivität
rat
Anwendung
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Natriumkanal-Antikörper, spannungsgesteuert, Schmerz (Segment SP19), Chemicon®, from rabbit,
Speziesreaktivität
mouse, rat
Anwendung
immunohistochemistry
western blot
western blot
Anti-Sodium Channel, Brain Type I (α subunit) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Speziesreaktivität
mouse, rat
Anwendung
immunohistochemistry
western blot
western blot
Monoklonaler Anti-Natriumkanal, Pan in Maus hergestellte Antikörper, ~1 mg/mL, clone K58/35, purified immunoglobulin,
Speziesreaktivität
mammals
Anwendung
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Blocker
Produktnummer
Beschreibung
Spezies
Lidocainhydrochlorid, Pharmaceutical Secondary Standard; Certified Reference Material,
Spezies
human