Figure 1.Blocking antibodies neutralize the interfering antibodies present in serum samples resulting in accurate binding of the analyte of interest by the capture and detection antibodies.
Recombinant Mouse IgG Antibody
Finding the right blocker against a disruptive protein present in immunoassay test samples can be difficult given the constraints on consistency, reliability, and availability. For this reason, we have developed a novel, sustainable replacement for mouse IgG purified from animal serum. The new recombinant mouse IgG antibody provides immunoassay manufacturers with a tightly controlled, non-animal derived blocking solution to efficiently reduce nonspecific antibody interference while improving lot reproducibility and test accuracy.
Recombinant Mouse IgG Antibody Formulations
We offer two animal-free mouse IgG blocker antibody formulations: Recombinant Mouse IgG B1 and Recombinant Mouse IgG B2, both supported by a secure supply chain. These new blends were developed from unique clones produced in stable cell lines expressed in CHO cells.
- Recombinant Mouse IgG B1 is formulated as a direct alternative to serum-derived mouse IgG and employs a passive blocking approach to eliminate interfering antibodies from immunoassay systems using capture and detection antibodies.
- Recombinant Mouse IgG B2 is an enhanced formulation of B1, designed to deliver a targeted blocking strategy against anti-mouse antibodies in immunoassay sample serums.
An internal study was conducted to compare these recombinant mouse IgG antibodies against the serum-derived mouse IgG blockers that are currently available in the market. The results showcased that in an ELISA test, at a concentration of 1 mg/mL, the blends provided equivalent to better blocking efficiency. Read Now.
Benefits of Recombinant Mouse IgG Antibody
These animal-free solution were primarily designed with enhanced blocking capability compared to serum-derived mouse IgG. Additionally, you can expect the following with these new blends:
Features | Benefits |
|---|---|
Cell culture, clonal-derived material | Limited variability between batches (lot reproducibility) |
Animal-free production | Sustainably sourced material |
Transportation regulatory barriers reduced | Simplified export/import requirements |
Eliminate pooled serum | Higher purity and lot-to-lot consistency |
Less complex material | Reduce/remove interfering substances |
Unique active mouse IgG recombinant antibody | Engineered as a targeted antibody blocker to specifically remove interfering antibodies like HAMA |
Two engineered clonal blends available | Diversifies assay-specific optimization options (passive vs targeted blocking) |
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