The journal of physical chemistry. B, 116(35), 10684-10692 (2012-08-07)
Diacylglycerol (DAG) regulates a broad range of cellular functions including tumor promotion, apoptosis, differentiation, and growth. Thus, the DAG-responsive C1 domain of protein kinase C (PKC) isoenzymes is considered to be an attractive drug target for the treatment of cancer
Biochemical and biophysical research communications, 430(1), 381-386 (2012-11-20)
Protocatechualdehyde (PCA) is a naturally occurring polyphenol found in barley, green cavendish bananas, and grapevine leaves. Although a few studies reported growth-inhibitory activity of PCA in breast and leukemia cancer cells, the underlying mechanisms are still poorly understood. Thus, we
Biochemical and biophysical research communications, 423(1), 116-121 (2012-05-30)
The migration and proliferation of vascular smooth muscle cells (VSMCs) and formation of intravascular thrombosis play crucial roles in the development of atherosclerotic lesions. This study examined the effects of protocatechuic aldehyde (PCA), a compound isolated from the aqueous extract
To investigate the pharmacokinetic interactions induced by content variation of the main water-soluble components of Danshen injection in rats. Intravenous Danshen injection (control) or Danshen injection with danshensu (DSS), protocatechuic aldehyde (PAL), salvianolic acid A (Sal A) or salvianolic acid
Journal of ethnopharmacology, 136(1), 129-136 (2011-04-30)
To evaluate the pharmacokinetics of phenolic compounds after oral administration of Danshen extract in rat brain. Blood and brain microdialysis probes were inserted into jugular vein and cerebral cortex of rat under anesthesia and perfused with ringer's solution at the
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