1683606

Triethyl citrate

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): Ethyl citrate
• Linear Formula: HOC(COOC₂H₅)(CH₂COOC₂H₅)₂
• CAS Number: 77-93-0
• Molecular Weight: 276.28
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329751393
• MDL number: MFCD00009201
• Beilstein/REAXYS Number: 1801199

Properties

• grade: pharmaceutical primary standard
• agency: USP
• vapor density: 9.7 (vs air)
• vapor pressure: 1 mmHg ( 107 °C)
• API family: triethyl citrate
• form: liquid
• manufacturer/tradename: USP
• greener alternative product characteristics: Less Hazardous Chemical Syntheses; Learn more about the Principles of Green Chemistry.
• sustainability: Sustainability features
• refractive index: n20/D 1.442 (lit.)
• bp: 235 °C/150 mmHg (lit.)
• density: 1.14 g/mL at 25 °C (lit.)
• application(s): USP Biologics; pharmaceutical (small molecule); pharmaceutical
• format: neat
• SMILES string: CCOC(=O)CC(O)(CC(=O)OCC)C(=O)OCC
• InChI: 1S/C12H20O7/c1-4-17-9(13)7-12(16,11(15)19-6-3)8-10(14)18-5-2/h16H,4-8H2,1-3H3
• InChI key: DOOTYTYQINUNNV-UHFFFAOYSA-N

Description

General description

Find answers to frequently asked questions on USP products in USP FAQs.

Triethyl citrate is used in microbiology primarily as a plasticizer in the formulation of biologics, where it enhances the flexibility of polymeric materials. In biologic product development, it is also used as a stabilizing agent in vaccines and other injectable therapeutics. Its role in drug formulations is crucial for maintaining the integrity and performance of biologic products over time.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product can replace highly toxic diluents in membrane preparation and thus aligns with "Less Hazardous Chemical Syntheses". Click here for more information.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

This product is part of USP Biologics Program.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Ph

Safety Information

• Storage Class: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): 311.0 °F - closed cup
• Flash Point (°C): 155 °C - closed cup