1125006

Chlorpromazine hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil
• Empirical Formula (Hill Notation): C₁₇H₁₉ClN₂S · HCl
• CAS Number: 69-09-0
• Molecular Weight: 355.33
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329749339
• MDL number: MFCD00012654
• Beilstein/REAXYS Number: 3779989

Properties

• grade: pharmaceutical primary standard
• agency: USP
• API family: chlorpromazine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule); pharmaceutical
• format: neat
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13
• InChI: 1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
• InChI key: FBSMERQALIEGJT-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)

Description

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chlorpromazine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Chlorpromazine
• Chlorpromazine Hydrochloride
• Chlorpromazine Hydrochloride Injection
• Chlorpromazine Hydrochloride Oral Concentrate
• Chlorpromazine Hydrochloride Syrup
• Chlorpromazine Hydrochloride Tablets

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Biochem/physiol Actions

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist, H₁ histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H301,H330
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• Precautionary Statements: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233