1019428

Amifostine thiol

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): WR-1065, 2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride, WR-1065 dihydrochloride
• Empirical Formula (Hill Notation): C₅H₁₄N₂S · 2HCl
• CAS Number: 14653-77-1
• Molecular Weight: 207.16
• NACRES: NA.24
• PubChem Substance ID: 329748973
• UNSPSC Code: 41116107
• MDL number: MFCD00460339

Properties

• grade: pharmaceutical primary standard
• agency: USP
• API family: amifostine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule); pharmaceutical
• format: neat
• storage temp.: −20°C
• SMILES string: Cl.Cl.NCCCNCCS
• InChI: 1S/C5H14N2S.2ClH/c6-2-1-3-7-4-5-8;;/h7-8H,1-6H2;2*1H
• InChI key: XDRLRDHLCIFZIW-UHFFFAOYSA-N

Description

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Amifostine thiol USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Amifostine
• Amifostine for Injection

Biochem/physiol Actions

WR-1065 is a cytoprotective cell-permeable ROS scavenge and an active metabolite of Amifostine.

WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Codes: H302,H318
• Precautionary Statements: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable