U6756

U-73122 hydrate

≥97.5% (HPLC), phospholipase C inhibitor, powder

• Synonym(s): 1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1H-pyrrole-2,5-dione
• Empirical Formula (Hill Notation): C₂₉H₄₀N₂O₃ · xH₂O
• CAS Number: 112648-68-7
• Molecular Weight: 464.64 (anhydrous basis)
• UNSPSC Code: 41106300
• PubChem Substance ID: 24278065
• NACRES: NA.77
• MDL number: MFCD12910450
• Assay: ≥97.5% (HPLC)
• Form: powder

Properties

• Product Name: U-73122 hydrate, powder
• assay: ≥97.5% (HPLC)
• Quality Segment: 100
• form: powder
• color: off-white
• solubility: ethanol: ~0.7 mg/mL, DMSO: ~0.9 mg/mL, chloroform: ~10 mg/mL, DMSO: ≤2.6 mg/mL (Achieved with heating.), ethanol: ≤5 mg/mL (Achieved with heating.), H₂O: insoluble
• storage temp.: room temp
• SMILES string: O.COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)C=CC5=O
• InChI: 1S/C29H40N2O3.H2O/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33;/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3;1H2/t23-,24-,25+,26+,29+;/m1./s1
• InChI key: WCOYJDRCHHGMRK-BDEPKWELSA-N

Description

Application

U-73122 hydrate has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na⁺ channel (ENaC) function in gerbil Reissner′s membranes (RMs)[1]. U-73122 has also been used to study local calcium responses in human umbilical vein endothelial cells (HUVECs)[2].

Biochem/physiol Actions

Inhibits the hydrolysis of PPI to IP₃, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of G protein-phospholipase C activation, while remaining unaffected by production of cAMP.

Features and Benefits

This compound is featured on the Phospholipase C page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

U-73122 hydrate is soluble in ethanol (approx. 0.7 mg/ml or ≤ 5 mg/ml with heating), chloroform (approx. 10 mg/ml) and DMSO (approx. 0.9 mg/ml or ≤ 2.6 mg/ml with heating). U-73122 hydrate is insoluble in water.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves