U104

UK 14,304

• Synonym(s): 5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Brimonidine
• Empirical Formula (Hill Notation): C₁₁H₁₀BrN₅
• CAS Number: 59803-98-4
• Molecular Weight: 292.13
• NACRES: NA.77
• PubChem Substance ID: 24277812
• UNSPSC Code: 12352200
• MDL number: MFCD00153878

Properties

• Quality Segment: 100
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL, DMSO: >6.5 mg/mL, ethanol: <8 mg/mL (warm), H₂O: insoluble
• SMILES string: Brc1c(NC2=NCCN2)ccc3nccnc13
• InChI: 1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
• InChI key: XYLJNLCSTIOKRM-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Application

UK 14,304 has been used in myenteric neurons to study the inhibition of R-type calcium currents[1]. UK 14,304 has also been used for immunofluorescence microscopy assays[2].

UK 14,304 has been used for the activation of extracellular signal-regulated kinase (ERK) in epicardial coronary artery culture

Biochem/physiol Actions

UK 14,304 is an α2-adrenoceptor agonist. UK 14,304 inhibits hormone-sensitive lipase (HSL) activity and suppresses lipogenesis in adipose tissue.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UK 14,304 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (<0.8 mg/mL), DMSO (>6.5 mg/ml) and ethanol (<8 mg/mL). However, it is insoluble in water.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable