By immunoblotting against the reduced protein, the antibody reacts with bands at ~24 kDa and 30 kDa (unglycosylated and glycosylated, respectively). It also reacts with non-reduced TIMP-3.
Immunogen
synthetic peptide corresponding to the first loop of human tissue inhibitor of metalloproteinase-3.
Physical form
Solution in phosphate buffered saline, pH 7.4, containing 50% glycerol and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
To determine the phenotypic and biochemical characteristics of the p.E139K missense variant in tissue inhibitor of metalloproteinase 3 (TIMP3) associated with Sorsby fundus dystrophy (SFD). The coding regions and adjacent intronic sequence of TIMP3 were amplified by polymerase chain reaction
Sorsby fundus dystrophy (SFD) is a macular degeneration caused by mutations in TIMP3, the majority of which introduce a novel cysteine. However, the exact molecular mechanisms underlying SFD remain unknown. We aimed to provide novel insights into the functional consequences
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
