T6704

Tandospirone

≥98% (HPLC)

• Synonym(s): (1R*,2S*,3R*,4S*)-N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-2,3-norbornanedicarboximide citrate salt, SM 3997
• Empirical Formula (Hill Notation): C₂₁H₂₉N₅O₂
• CAS Number: 87760-53-0
• Molecular Weight: 383.49
• UNSPSC Code: 51111800
• PubChem Substance ID: 329826853
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• storage condition: protect from light
• solubility: DMSO: 38 mg/mL
• originator: Dainippon Sumitomo
• storage temp.: 2-8°C
• SMILES string: O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1CCCCN4CCN(CC4)c5ncccn5
• InChI: 1S/C21H29N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3,6-7,15-18H,1-2,4-5,8-14H2/t15-,16+,17+,18-
• InChI key: CEIJFEGBUDEYSX-FZDBZEDMSA-N

Description

Biochem/physiol Actions

Tandospirone is a partial agonist at 5HT_1A receptors. It significantly reduces haloperidol-induced bradykinesia in a dose-dependent manner. The potency of tandospirone is equal to that of buspirone and approximate half that of diazepam. The potency of tandospirone as a dopamine antagonistic is less than 1/4 that of buspirone.

Features and Benefits

This compound was developed by Dainippon Sumitomo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable