T5443

Tyrphostin AG 825

≥92.5%

• Synonym(s): 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide, Tyrphostin C15
• Empirical Formula (Hill Notation): C₁₉H₁₅N₃O₃S₂
• CAS Number: 149092-50-2
• Molecular Weight: 397.47
• NACRES: NA.77
• PubChem Substance ID: 329826823
• UNSPSC Code: 12352200
• MDL number: MFCD01074971
• Assay: ≥92.5%
• Form: powder

Properties

• Quality Segment: 200
• assay: ≥92.5%
• form: powder
• solubility: DMSO: soluble, methanol: soluble
• storage temp.: −20°C
• SMILES string: COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O
• InChI: 1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
• InChI key: KXDONFLNGBQLTN-WUXMJOGZSA-N

Description

Application

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells¹.

Biochem/physiol Actions

EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.

Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells².

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Tyrphostin AG 825 is soluble in DMSO and methanol.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)