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T4069

Sigma-Aldrich

JC-1

≥97% purity, solid

Synonym(s):

5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide, CBIC2(3)

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5 MG
CZK 28,600.00

CZK 28,600.00

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5 MG
CZK 28,600.00

About This Item

Empirical Formula (Hill Notation):
C25H27Cl4IN4
CAS Number:
3520-43-2
Molecular Weight:
652.23
MDL number:
MFCD00188475
UNSPSC Code:
12171500
PubChem Substance ID:
24900193
NACRES:
NA.47

CZK 28,600.00

Please contact Customer Service for Availability
Request a Bulk Order

Product Name

JC-1, powder or solid (Crystals)

Assay

≥97%

Quality Level

100

form

powder or solid (Crystals)

technique(s)

titration: suitable

color

faint red to very dark red

ε (extinction coefficient)

≥175000 at 511-517 nm in methanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[I-].CCN1C(=C\C=C\c2n(CC)c3cc(Cl)c(Cl)cc3[n+]2CC)/N(CC)c4cc(Cl)c(Cl)cc14

InChI

1S/C25H27Cl4N4.HI/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4;/h9-15H,5-8H2,1-4H3;1H/q+1;/p-1

InChI key

FYNNIUVBDKICAX-UHFFFAOYSA-M

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Application

A dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent (λex 520 nm) monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent (λem 596 nm ) "J-aggregates," which exhibit broad excitation and very narrow emission spectra. The ratio of red to green fluorescence of JC-1 is dependent only on membrane potential, and not influenced by mitochondrial size, shape, or density.
The cyanine dye[1] JC-1 has been used to determine mitochondrial transmembrane potential.[2][3][4]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW5291
MKCT7568
MKCT1231
MKCS4169
MKCQ7414

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Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion
Li L
Cell Death & Disease (2016)
Qiong Wang et al.
Acta biomaterialia, 94, 469-481 (2019-05-30)
Multi-drug resistance (MDR) of tumor is a major cause of chemotherapy failure. In this study, a pH-sensitive graft copolymer, poly(β-amino ester)-g-β-cyclodextrin (PBAE-g-β-CD), was synthesized via Michael addition polymerization and was employed to co-deliver doxorubicin (DOX), a chemotherapy agent, and adjudin
Shumin Qin et al.
Frontiers in pharmacology, 10, 894-894 (2019-09-03)
Alcohol consumption affects gastric mucosa by multiple and complex mechanisms depending either by direct contact of ethanol or by indirect biological damage induced by its metabolite acetaldehyde. The present study aims at further investigating the mechanism of ethanol-induced gastric mucosa
JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry
A Perelman
Cell Death & Disease (2012)
Xianbin Cao et al.
Cellular signalling, 62, 109337-109337 (2019-06-08)
Radiation-induced tumor cells death is the theoretical basis of tumor radiotherapy. Death signaling disorder is the most important factor for radioresistance. However, the signaling pathway(s) leading to radiation-triggered cell death is (are) still not completely known. To better understand the
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Questions

  1. Mitochondria Staining Kit (CS0390)에 들어있는 1MG-JC-1 powder와 다른 제품인가요? 동일 농도로 DMSO이용해 녹였더니 Stock 색상이 다릅니다.

    1 answer

    1. Yes, the T4069, JC-1 product is also supplied in the Mitochndria Stain kit, CS0390. Both are prepared at 1 mg/mL in DMSO resulting in a red solution. Slight variations in color may be considered normal and the result of lot-to-lot variability. Marked differences in color should be discussed with Technical Service.

      Should this be the case, please navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquiries" under the Products Section and respond with all the required information so that a member of the Technical Service team can reach out to assist further. Thank you.

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