When filter sterilized, aqueous solutions are expected to be stable at 4 °C for 5-10 days or in aliquots at -20°C for extended periods. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/971/085/t3309pis.pdf
T3309
Transferrin human
≥98%
Synonym(s):
Siderophilin, partially saturated
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Please contact Customer Service for Availability | CZK 4,560.00 |
500 mg | Please contact Customer Service for Availability | CZK 18,300.00 |
1 g | Please contact Customer Service for Availability | CZK 25,000.00 |
About This Item
CAS Number:
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.61
MDL number:
eCl@ss:
34058011
Form:
powder
Assay:
≥98%
Biological source:
human
General description
Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.
Application
Transferrin has been used:
- in isolation of epidermal stem cells and cell expansion[1]
- to study the effect of compound treatment on transferrin uptake
- for transferrin uptake and confocal imaging
Biochem/physiol Actions
Transferrin was shown to promote the proliferation of human lymphocytes. This effect is directly proportional to the level of iron present. [2]
Transferrin facilitates the transfer of iron to erythron and peripheral tissues. Mutations in this gene is associated with atransferrinemia. Transferrin is required for fetal development. It is non immunogenic and transferrin-conjugated drugs inhibits cardiotoxicity and drug resistance.
Analysis Note
Purity by agarose electrophoresis.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| biological source human | biological source - | biological source human | biological source - |
| technique(s) cell culture | stem cell: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| assay ≥98% | assay ≥98% | assay ≥95% protein basis (biuret), ≥98% (agarose gel electrophoresis) | assay ≥98% (agarose gel electrophoresis) |
| form powder | form powder | form powder | form powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
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How long is this product (Transferrin human, T3309) stable upon reconstitution in water?
1 answer-
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HOW IS THIS PROTEIN PRODUCED AND WHAT IS THE REST 2% IMPURITY? THANKS!
1 answer-
This product is prepared by an ammonium sulfate precipitation process followed by a heat treatment and ion exchange chromatography purification. The specific details are considered proprietary. There is no treatment or handling during production that would be expected to cause deglycosylation of the protein. The residual impurities have not been identified. This product is tested for endotoxin and iron. Please see the Sample Certificates of Analysis: https://www.sigmaaldrich.com/certificates/Graphics/COfAInfo/fluka/pdf/PDF746107.pdf
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the carbohydrate content of human transferrin?
1 answer-
We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.
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