T2825

TIQ-A

≥98% (HPLC), solid

• Synonym(s): Thieno[2,3-c]isoquinolin-5-one
• Empirical Formula (Hill Notation): C₁₁H₇NOS
• CAS Number: 420849-22-5
• Molecular Weight: 201.24
• NACRES: NA.77
• PubChem Substance ID: 24724630
• UNSPSC Code: 12352200
• MDL number: MFCD06407947
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: soluble 16 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C1Nc2sccc2-c3ccccc13
• InChI: 1S/C11H7NOS/c13-10-8-4-2-1-3-7(8)9-5-6-14-11(9)12-10/h1-6H,(H,12,13)
• InChI key: LQJVOLSLAFIXSV-UHFFFAOYSA-N

Description

Application

TIQ-A has been used as a PAPR-1 inhibitor to study eosinophilic infiltration into the airways of OVA-challenged mice¹. It has also been used to study its role in the regression of atherosclerotic plaques in high-fat diet-fed ApoE(-/-) mice².

Biochem/physiol Actions

TIQ-A is a potent inhibitor of PARP, anti-apoptotic.

Preparation Note

TIQ-A is soluble in DMSO at 16 mg/ml.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves