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T133

Inactin® hydrate

≥98% (HPLC), Anethetic reagent, powder

Synonym(s):

Thiobutabarbital sodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C10H15N2NaO2S · xH2O
CAS Number:
947-08-0
Molecular Weight:
250.29 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24899957
UNSPSC Code:
12352200
EC Number:
213-425-3
MDL number:
MFCD00214068
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Product Name

Inactin® hydrate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

color

light yellow

solubility

H2O: soluble (storage of solutions for more than 8 hours at 4°C is not recommended.)

SMILES string

[Na+].CCC(C)C1(CC)C([O-])=NC(=S)NC1=O

InChI

1S/C10H16N2O2S.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1

InChI key

SLZHLQUFNFXTHB-UHFFFAOYSA-M

Application

Inactin® hydrate has been used to anesthetize rats to study stress-induced hypersensitivity[1] and mice to study Cisplatin-induced neuropathy.[2] It has also been used to anesthetize rats to measure the glomerular filtration rate (GFR).[3]

Biochem/physiol Actions

Inactin® is a long-lasting rodent anesthetic with minimal effects on cardiovascular tone and renal output. It exhibits sedative and hypnotic properties.

Legal Information

Inactin is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000521574
0000521576
0000521576
0000521575
0000521574

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Maki Niihori et al.
American journal of respiratory cell and molecular biology, 62(2), 231-242 (2019-08-29)
NFU1 is a mitochondrial protein that is involved in the biosynthesis of iron-sulfur clusters, and its genetic modification is associated with disorders of mitochondrial energy metabolism. Patients with autosomal-recessive inheritance of the NFU1 mutation G208C have reduced activity of the
Flecknell
Laboratory Animal Anesthesia. An introduction for Research Workers and Technicians, 36-36 (1987)
Min-Suk Yoon et al.
BMC neuroscience, 10, 77-77 (2009-07-16)
Cisplatin mediates its antineoplastic activity by formation of distinct DNA intrastrand cross links. The clinical efficacy and desirable dose escalations of cisplatin are restricted by the accumulation of DNA lesions in dorsal root ganglion (DRG) cells leading to sensory polyneuropathy
View All Related Papers

Global Trade Item Number

SKUGTIN
SAB1306335-400UL04061835642977
T133-5X1G04061832561295
T133-1G04061826203996
T133-25X1G04061837337178

Questions

  1. How should item T133, Inactin® hydrate be reconstituted and stored?

    1 answer

    1. Item T133, Inactin® hydrate, is soluble in water. According to our website, after reconstitution in water, storing solutions for more than 8 hours at 4°C is not recommended.

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