T0826
TBB
≥98% (HPLC), solid
Synonym(s):
4,5,6,7-Tetrabromo-2-azabenzimidazole, 4,5,6,7-Tetrabromobenzotriazole, NSC 231634, TBBt
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| Size/SKU | Availability | Price |
|---|---|---|
10 mg | Please contact Customer Service for Availability | CZK 7,050.00 CZK 5,992.50 |
About This Item
Empirical Formula (Hill Notation):
C6HN3Br4
CAS Number:
Molecular Weight:
434.71
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
CZK 5,992.50
List PriceCZK 7,050.00Save 15%Please contact Customer Service for Availability
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: 28 mg/mL
storage temp.
2-8°C
SMILES string
Brc1c(Br)c(Br)c2[nH]nnc2c1Br
InChI
1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
InChI key
OMZYUVOATZSGJY-UHFFFAOYSA-N
Application
TBB was used to study casein kinase 2-dependent phosphorylation of DNA damage mediator protein MDC1.[1]
Biochem/physiol Actions
TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP.[2] TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.[3]
TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 mM, using rat liver and recombinant human CK2, respectively).
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form solid | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 28 mg/mL | solubility DMSO: >10 mg/mL at 60 °C, clear | solubility DMSO: 2 mg/mL, clear | solubility - |
| color white | color - | color white to beige | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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