T0201

Tau-381 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder

• UNSPSC Code: 12352200
• NACRES: NA.32
• MDL number: MFCD07785731
• Form: lyophilized powder
• Assay: ≥90% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in E. coli
• Mol wt: 39.7 kDa

Properties

• biological source: human
• Quality Segment: 200
• recombinant: expressed in E. coli
• assay: ≥90% (SDS-PAGE)
• form: lyophilized powder
• mol wt: 39.7 kDa
• UniProt accession no.: P10636
• application(s): cell analysis
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... MAPT(4137)

Description

General description

The gene microtubule associated protein tau (MAPT) is localized on human chromosome 17q21.3. It is expressed in neurons, more specifically in axons.

Biochem/physiol Actions

Isoform of Tau, variant 1N3R, having 3 microtubule binding repeats (R) and one amino terminal insert (N).

Microtubule associated protein tau (MAPT) aids in the assembly and maintenance of microtubule structure. Loss of expression of MAPT results in developmental delay and learning disability. The protein has been associated with pathology of Alzheimer′s disease (AD).

Preparation Note

Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA.

Safety Information

• Storage Class: 11 - Combustible Solids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)