SML3722

Dinaciclib

≥98% (HPLC)

• Synonym(s): (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol, 2-[(2S)-1-[3-Ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol, MK 7965, MK-7965, MK7965, SCH 727965, SCH-727965, SCH727965
• Empirical Formula (Hill Notation): C₂₁H₂₈N₆O₂
• CAS Number: 779353-01-4
• Molecular Weight: 396.49
• UNSPSC Code: 12352200
• NACRES: NA.21
• MDL number: MFCD16037702
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , White to light brown
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: [n+]1(cc(ccc1)CNC2=CC(=Nc4[n]2ncc4CC)N3[C@@H](CCCC3)CCO)[O-]
• InChI key: PIMQWRZWLQKKBJ-SFHVURJKSA-N

Description

Biochem/physiol Actions

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor (CDK1/2/5/6/7/9 IC50 = 3/1/1/12/7/4 nM; Little or no inhibition of 41 other kinases at 10 μM) with potent antiproliferation activity in A2780 ovarian cancer cultures (IC50 = 4 nM by thymidine uptake assays). Dinaciclib exhibits potent anti-cancer efficacy in cultures (IC50 = 6-17 nM against 14 cancer cell lines) and in an A2780 tumor xenograft model in mice in vivo (8-48 mg/kg via daily i.p.).

Potent and selective cyclin-dependent kinase (CDK) inhibitor with potent anti-cancer efficacy in cultures and in mice in vivo.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable