SML3715
SSK1
≥98% (HPLC)
Synonym(s):
(2R,3S,4S,5R,6S)-2-(acetoxymethyl)-6-(4-((((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)oxy)methyl)-2-nitrophenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate
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About This Item
Empirical Formula (Hill Notation):
C31H34F2N4O18
CAS Number:
Molecular Weight:
788.61
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Galactose-conjugated senolytic prodrug; induces apoptosis in senescence cells through activation of p38 MAPK
SSK1 is a senescence cells specific killing agent that is activated by lysosomal β-galactosidase. SSK1 induces apoptosis in senescence cells through activation of p38 MAPK. Also, it induces mitochondrial DNA damage in senescent cells. In aged mice, SSK1 removes senescence cells in different tissues, attenuated low-grade inflammation and improved physical function.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description Pharmaceutical Analytical Impurity (PAI) | description United States Pharmacopeia (USP) Reference Standard | description - |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| form powder | form - | form solid | form solid |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 100 |
| storage temp. -10 to -25°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. - |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - | solubility - |
| color white to beige | color - | color - | color - |
![3′-Demethyl-3′-N-[(4-Methylphenyl)Sulfonyl]Azithromycin Pharmaceutical Analytical Impurity (PAI)](/deepweb/assets/sigmaaldrich/product/images/143/551/573a54d2-d905-4d69-9c24-0434b1060620/640/573a54d2-d905-4d69-9c24-0434b1060620.jpg)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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