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SML3697

Anagliptin

≥98% (HPLC)

Synonym(s):

(S)-N-(2-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethylamino)-2-methylpropyl)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide, N-[2-({2-[(2S)-2-Cyanopyrrolidine-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide, SK 0403, SK-0403, SK0403

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About This Item

Empirical Formula (Hill Notation):
C19H25N7O2
CAS Number:
Molecular Weight:
383.45
UNSPSC Code:
51111800
NACRES:
NA.21
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

[n]21nc(cc2ncc(c1)C(=O)NCC(NCC(=O)N3[C@@H](CCC3)C#N)(C)C)C

InChI

1S/C19H25N7O2/c1-13-7-16-21-9-14(11-26(16)24-13)18(28)22-12-19(2,3)23-10-17(27)25-6-4-5-15(25)8-20/h7,9,11,15,23H,4-6,10,12H2,1-3H3,(H,22,28)/t15-/m0/s1

InChI key

LDXYBEHACFJIEL-HNNXBMFYSA-N

Biochem/physiol Actions

Anagliptin is an orally active, potent and selective dipeptidyl peptidase 4 (DPP-IV; DPP4) inhibitor (DPP4/8/9 IC50 = 3.8/68/60 nM). When administered in vivo (0.3% w/w in diet), anagliptin shows anti-atherosclerotic efficay in apoE-deficient mice and ameliorates diabetes in mice with haploinsufficiency of glucokinase on a high-fat diet.
Orally active, potent and selective dipeptidyl peptidase 4 (DPP-IV; DPP4) inhibitor with anti-atherosclerotic and anti-diabetic efficacy in vivo.

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This Item
SML2393PHR1343135186
description

≥98% (HPLC)

description

≥98% (HPLC)

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

99%

form

powder

form

powder

form

-

form

liquid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

99%

Quality Level

100

Quality Level

-

Quality Level

300

Quality Level

200

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL

solubility

-

solubility

-

color

white to beige

color

white to beige

color

-

color

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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