SML3623

DSRM-3716

≥98% (HPLC)

• Synonym(s): 5-Iodoisoquinoline, DSRM 3716, DSRM3716
• Empirical Formula (Hill Notation): C₉H₆IN
• CAS Number: 58142-99-7
• Molecular Weight: 255.06
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD11226893
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , yellow to light brown
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C
• SMILES string: Ic1c2c(cncc2)ccc1
• InChI key: CUILFTFMBBGSFT-UHFFFAOYSA-N

Description

Biochem/physiol Actions

DSRM-3716 is a potent and selective SARM1 NADase inhibitor (NAD+ hydrolysis IC50 = 75 nM using recombinant SARM1 SAM-TIR construct) that recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy (EC50 = 2.1/1.9 µM by fragmentation/NfL release using mouse DRG neurons; 81/88% protection by 1/3 µM DSRM-3716 using human iPSC-derived motor neurons) or mitochondrial dysfunction (3-30 µM DSRM-3716 against 25 µM rotenone-induced injury; mouse DRG neurons). Mechanistically, DSRM-3716 undergoes base exchange with the nicotinamide (NAM) moiety of nicotinamide adenine dinucleotide (NAD+) to yield the bona fide inhibitor 1AD.

Potent and selective SARM1 NADase inhibitor that protects axons from degeneration induced by axotomy or mitochondrial dysfunction.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H302,H311,H315,H319,H412
• Precautionary Statements: P264 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable