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SML3574

5-Ph-IAA

≥97% (HPLC), auxin-inducible degron (AID) ligand, powder

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Synonym(s):

2-(5-Phenyl-1H-indol-3-yl)acetic acid, 5-Phenyl-1H-indole-3-acetic acid, 5-Phenyl-indole-3-acetic acid

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Size/SKUAvailabilityPrice
5 mg
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2 030,00 CZK
25 mg
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8 200,00 CZK

About This Item

Empirical Formula (Hill Notation):
C16H13NO2
CAS Number:
Molecular Weight:
251.28
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
Assay:
≥97% (HPLC)
Form:
powder

2 030,00 CZK

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Product Name

5-Ph-IAA, ≥97% (HPLC)

Quality Segment

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(CC1=CNC2=CC=C(C3=CC=CC=C3)C=C21)O

InChI key

ACCCWYHBDGKDKN-UHFFFAOYSA-N

Biochem/physiol Actions

5-Ph-IAA is a bumped auxin-inducible degron (AID) ligand that induces Skp1-Cul1-F-box (SCF) E3 ligase complex-mediated ubiquitinaton of Arabidopsis IAA17-derived mini-AID (mAID) degron-fused target proteins in cells expressing a hole-modified Oryza sativa TIR1 (OsTIR1) mutant (F74G or F74A). Unlike the traditional AID system, 5-Ph-IAA-based AID2 method shows no detectable leaky degradation, requires a 670-times lower ligand concentration, and achieves quicker degradation in cultures (0.2-5 μM) and in vivo (1-10 mg/kg via daily i.p. to mice xenografted with HCT116 CMV-OsTIR1(F74G) cells expressing mAID-tagged BRD4 or TOP2A).
Bumped AID2 system ligand that induces degradation of IAA17-derived mini-AID (mAID) degron-fused target proteins in cultures and in vivo.

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This Item
SML2533SML3499SML1926
description

≥97% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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