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SML3419

Koumine

≥95% (HPLC)

Synonym(s):

(3S,4S,4aR,6R,11bS,11cS)-11c-Ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-6,4, CID 91895267

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About This Item

Empirical Formula (Hill Notation):
C20H22N2O
CAS Number:
Molecular Weight:
306.40
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
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Quality Segment

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D 295 to 245°

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

InChI key

VTLYEMHGPMGUOT-MKWZCHDOSA-N

Biochem/physiol Actions

Koumine is a major indole alkaloid isolated from poisonous plant Gelsemium elegans that exhibits anti-inflammatory and analgesic effects in inflammatory and neuropathic pain models. It appears that koumine ameliorate chronic constriction injury induced neurotic pain through induction of autophagy and the inhibition apoptosis in the spinal cord of rodents. Koumine protects IPEC-J2 cells from hydrogen peroxide induced oxidative stress and apoptosis through decreasing reactive oxygen species (ROS) production.
Major indole alkaloid isolated from poisonous plant Gelsemium elegans that exhibits anti-inflammatory and analgesic effects

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This Item
PHL84231SML3429SML3615
Koumine phyproof® Reference Substance

PHL84231

Koumine

description

≥95% (HPLC)

description

phyproof® Reference Substance

description

≥98% (HPLC)

description

≥95% (HPLC)

form

powder

form

solid

form

powder

form

powder

assay

≥95% (HPLC)

assay

≥90.0% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

-10 to -25°C

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

-

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

DMSO: 2 mg/mL, clear (Warmed)

color

white to beige

color

-

color

white to beige

color

white to beige


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pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3



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