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SML3411

LY2828360

≥98% (HPLC)

Synonym(s):

8-(2-Chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine, LY 2828360

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About This Item

Empirical Formula (Hill Notation):
C22H27ClN6O
CAS Number:
Molecular Weight:
426.94
UNSPSC Code:
41121800
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

Clc1c(cccc1)c2[n](c4nc(nc(c4n2)N5CCN(CC5)C)C)C3CCOCC3

InChI

1S/C22H27ClN6O/c1-15-24-21(28-11-9-27(2)10-12-28)19-22(25-15)29(16-7-13-30-14-8-16)20(26-19)17-5-3-4-6-18(17)23/h3-6,16H,7-14H2,1-2H3

InChI key

UCMNDPDJRSEZPL-UHFFFAOYSA-N

Biochem/physiol Actions

LY2828360 is a potent and selective slowly acting G protein-biased CB2 cannabinoid agonist that inhibits cAMP accumulation and activates ERK1/2 signaling while failing to recruit arrestin. LY2828360 suppress chemotherapy-induced neuropathic pain created by paclitaxel without producing tolerance in mice.
Potent and selective slowly acting G protein-biased CB2 cannabinoid agonist

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This Item
G8173C1358AB5642P
description

≥98% (HPLC)

description

≥98% (HPLC), powder

description

affinity isolated antibody, buffered aqueous glycerol solution

description

Chemicon®, from rabbit

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

form

powder

form

powder

form

buffered aqueous glycerol solution

form

-

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

DMSO: ≥20 mg/mL

solubility

-

solubility

-

color

white to beige

color

off-white to light brown

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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