SML3366

SIS17

≥95% (HPLC)

• Synonym(s): N′-Hexadecylthiophene-2-carbohydrazide, SIS 17, SIS-17
• Empirical Formula (Hill Notation): C₂₁H₃₈N₂OS
• CAS Number: 2374313-54-7
• Molecular Weight: 366.60
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD32201127
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C
• SMILES string: [s]1c(ccc1)C(=O)NNCCCCCCCCCCCCCCCC
• InChI: 1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24)
• InChI key: HSHXDCVZWHOWCS-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Potent and selective HDAC11 inhibitor that effectively upregulates cellular serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level.

SIS17 is a potent and selective HDAC11 inhibitor (IC50 = 830 nM; IC50 >100 μM against HDAC1/4/8 or SIRT1/2/3/6) that effectively upregulates HDAC11 substrate, serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level in MCF7 cells (12.5 μM).

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable