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SML3337

CBR-470-1, racemic

≥98% (HPLC)

Synonym(s):

(± )-3-((4-chlorophenyl)sulfonyl)-4-(isobutylamino)tetrahydrothiophene 1,1-dioxide, 3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel- (ACI)

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About This Item

Empirical Formula (Hill Notation):
C14H20ClNO4S2
CAS Number:
Molecular Weight:
365.90
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2%, clear

storage temp.

2-8°C

Biochem/physiol Actions

CBR-470-1 is an Inhibitor of the glycolytic enzyme PGK1 that induces Nrf2 activity. PGK1 inhibition results in acculumation of methylglyoxalyl (MGO), a toxic, reactive metabolite removed by other enzymes. The accumulated MGO then irreversibly reacts with Keap1 forming inactive Keap1 dimers, resulting in accumulation of Nrf2.
Inhibitor of the glycolytic enzyme PGK1 inducing Nrf2 activity

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This Item
SML3609SML1983SML1804
description

≥98% (HPLC)

description

≥95% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2%, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL to clear

solubility

DMSO: 2 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

white to brownish

color

white to brown


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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