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About This Item
Empirical Formula (Hill Notation):
C43H48N10O6S
CAS Number:
Molecular Weight:
832.97
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
O=C([C@H](C(C)(C)C)NC(CCCNC(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)=O)=O)N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5
InChI key
PPNNFXIBKLCMTI-WXEAQWFJSA-N
Biochem/physiol Actions
UNC6852 is a potent degrader of polycomb repressive complex 2 (PRC2) that targets EED. UNC6852 selectively degrades PRC2 components EED (embryonic ectoderm development), EZH2 (enhancer of zeste homolog 2), and SUZ12 (suppressor of zeste homolog 12) via recruitment of VHL. UNC6852 exhibit anticancer activities in model systems.
potent degrader of polycomb repressive complex 2 (PRC2) that targets EED
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥90% (HPLC) | description ≥98% (HPLC) |
| form powder | form - | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥90% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. -10 to -25°C | storage temp. −20°C |
| solubility DMSO: 2 mg/mL, clear (Warmed) | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear (Warmed) | solubility DMSO: 10 mg/mL, clear |
| color white to beige | color white to beige | color white to beige | color white to beige |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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