SML3316

TQS

≥98% (HPLC)

• Synonym(s): 3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopenta[c]quinoline-8-sulfonamide
• Empirical Formula (Hill Notation): C₂₂H₂₀N₂O₂S
• CAS Number: 353483-92-8
• Molecular Weight: 376.47
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD01080566
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NS(C1=CC2=C(NC(C3=CC=CC4=C3C=CC=C4)C5C2C=CC5)C=C1)(=O)=O
• InChI: 1S/C22H20N2O2S/c23-27(25,26)15-11-12-21-20(13-15)17-8-4-10-19(17)22(24-21)18-9-3-6-14-5-1-2-7-16(14)18/h1-9,11-13,17,19,22,24H,10H2,(H2,23,25,26)
• InChI key: SIZWDJIHABLBSP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

α7nAChR positive allosteric modulator

TQS is a type-II positive allosteric modulator of α7 nAChR. TQS potentiates agonist-invoked responses, and dramatically reduces the rate of desensitization of α7 nAChR. The compound has no agonist activity alone. The EC₅₀ for potentiation of submaximal doses of acetylcholine is 6.2µM.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable