SML3301

cisVZ185

≥98% (HPLC)

• Synonym(s): (2S,4S)-N-(2-(5-(4-(2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyloxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide, Cis-VZ 185, Cis-VZ-185, Cis-VZ185, VZ 185 inactive control, VZ 185 negative control, VZ-185 inactive control, VZ185 inactive control, VZ185 negative control
• Empirical Formula (Hill Notation): C₅₃H₆₇FN₈O₈S
• CAS Number: 2306193-98-4
• Molecular Weight: 995.21
• UNSPSC Code: 51111800
• NACRES: NA.32
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C(NCC1=C(OCCCCCN2CCN(CC3=C(OC)C=C(C(C4=C5C=NC=C4)=CN(C)C5=O)C=C3OC)CC2)C=C(C=C1)C6=C(C)N=CS6)[C@H]7N(C([C@@H](NC(C8(F)CC8)=O)C(C)(C)C)=O)C[C@@H](O)C7
• InChI key: ZAGCLFXBHOXXEN-ZLGHNAGESA-N

Description

Biochem/physiol Actions

Inactive cis-isomer of and the negative control for the potent and selective PROTAC BRD7/9 degrader VZ185.

cisVZ185 is the inactive cis-isomer of and the recommended negative control for the potent and selective dual BRD7 and BRD9 degrader VZ185.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable