SML3242

MR6-31-2

≥98% (HPLC)

• Synonym(s): 2-(4-Chlorobenzyl)benzo[d][1,2]selenazol-3(2H)-one, 2-[(4-Chlorophenyl)methyl]-1,2-benzisoselenazol-3(2H)-one
• Empirical Formula (Hill Notation): C₁₄H₁₀ClNOSe
• CAS Number: 2524641-00-5
• Molecular Weight: 322.65
• UNSPSC Code: 12352107
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• storage temp.: 2-8°C
• SMILES string: O=C1N(CC2=CC=C(Cl)C=C2)[Se]C3=CC=CC=C31
• InChI: 1S/C14H10ClNOSe/c15-11-7-5-10(6-8-11)9-16-14(17)12-3-1-2-4-13(12)18-16/h1-8H,9H2
• InChI key: XZWKXIFLMYRVTK-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CNS penetrant potent inhibitor of SARS-CoV-2 Mpro that bind at the Mpro catalytic site

MR6-31-2, a CNS penetrant ebselen analog, is a potent inhibitor of SARS-CoV-2 Mpro that bind at the Mpro catalytic site. MR6-31-2 donates a selenium atom, forming a covalent bond and blocking the histidine-Cys catalytic dyad. It exhibits good neuroprotective effects and low cytotoxicity in cell-based and mouse models of motor neuron disease. MR6-31-2 covalently binds to A4V superoxide dismutase-1 (SOD1) and promotes its thermal stability.

Safety Information

• Pictograms: GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Codes: H301 + H331,H373,H410
• Precautionary Statements: P260 - P264 - P273 - P301 + P310 - P304 + P340 + P311 - P314
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3