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SML3135

Cinobufagin

≥98% (HPLC)

Synonym(s):

14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate, 5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate, 14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate, 5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
2 440,00 CZK
25 mg
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7 800,00 CZK

About This Item

Empirical Formula (Hill Notation):
C26H34O6
CAS Number:
Molecular Weight:
442.54
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

2 440,00 CZK


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

C[C@]([C@@H](C(C=C1)=COC1=O)[C@H]2OC(C)=O)(CC[C@@]3([H])[C@@]4([H])CC[C@@]5([H])[C@@]3(CC[C@H](O)C5)C)[C@@]64[C@@H]2O6

InChI

1S/C26H34O6/c1-14(27)31-22-21(15-4-7-20(29)30-13-15)25(3)11-9-18-19(26(25)23(22)32-26)6-5-16-12-17(28)8-10-24(16,18)2/h4,7,13,16-19,21-23,28H,5-6,8-12H2,1-3H3/t16-,17+,18+,19-,21+,22-,23-,24+,25-,26-/m1/s1

InChI key

SCULJPGYOQQXTK-OLRINKBESA-N

Biochem/physiol Actions

Cinobufagin is a bufanolide steroid with anti-proliferative and pro-apoptotic effects as well as antinociception activity. It has been used in Chinese herbal medicine and has been shown to have clinical applications in a variety of cancers both as an anticancer agent and to reduce cancer pain. Cinobufagin was recently identified as novel expression-mimicker that exert in vitro as well as in vivo anti-AML efficacy against AML expressing mtRUNX1.

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This Item
PHL89609B0261203900
description

≥98% (HPLC)

description

phyproof® Reference Substance

description

-

description

A cardiotonic steroid isolated from toads of Bufo species that potently inhibits ouabain-sensitive Na+,K+-ATPase activity (IC50 = 1.4 nM).

assay

≥98% (HPLC)

assay

≥95.0% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

form

powder

form

-

form

solid

form

solid

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

DMF: soluble, DMSO: soluble, ethanol: soluble

solubility

DMSO: 25 mg/mL, warm ethanol: 25 mg/mL

color

white to beige

color

-

color

-

color

white to off-white


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Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Codes

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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