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About This Item
Empirical Formula (Hill Notation):
C22H29N3 · 2CF3CO2H
CAS Number:
Molecular Weight:
563.53
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC1=CC=CC([C@H]2CC[C@@H](N3CCN(C4=CN=CC=C4)CC3)CC2)=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
InChI key
UMKPISXYUQWXJJ-XWOHEVPJSA-N
Biochem/physiol Actions
Potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor that selectively inhibits the growth of TrpV6-expressing, but not TrpV6-negative cancer cultures.
cis-22a is a potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor (Cd2+ influx IC50 = 320 nM; hTRPV6 transfected HEK293) with much reduced and little potency against other calcium channels and related TRP targets. cis-22a selectively inhibits the growth of TrpV6-expressing breast cancer T47D (IC50 = 25 μM), but not TrpV6-negative ovarian carcinoma SKOV3 cultures (IC50 >50 μM).
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: 2 mg/mL, clear | solubility DMSO: 10 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear |
| color white to beige | color white to beige | color white to beige | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3112-5MG | 04065267225395 |
| SML3112-25MG | 04065267225388 |



