SML3079
Ponalrestat
≥98% (HPLC)
Synonym(s):
3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid, ICI 128436, MK538
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Pack Size | SKU | Availability | Price |
|---|
About This Item
Empirical Formula (Hill Notation):
C17H12BrFN2O3
CAS Number:
Molecular Weight:
391.19
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Pricing and availability is not currently available.
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC(CC(C1=CC=CC=C1C2=O)=NN2CC3=CC=C(C=C3F)Br)=O
InChI
1S/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23)
InChI key
LKBFFDOJUKLQNY-UHFFFAOYSA-N
Biochem/physiol Actions
Ponalrestat is an orally available, potent and specific inhibitor of aldehyde reductase 2 (ALR2) that blocks the conversion of glucose to sorbitol. Ponalrestat promotes root elongation through the inhibition of the flavin monooxygenase YUCCA in Arabidopsis.
orally available, potent and specific inhibitor of aldehyde reductase 2 (ALR2)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Ajmer Singh Grewal et al.
Mini reviews in medicinal chemistry, 16(2), 120-162 (2015-09-10)
Diabetes mellitus occurrence has been associated to the modification of the physiological levels of glucose and is often accompanied by several long-term complications, namely neuropathy, nephropathy, retinopathy, cataract, and cardiovascular. Aldose reductase (AR) is an enzyme of aldoketo reductase super-family
Guang Wang et al.
Chemical research in toxicology, 33(8), 2164-2171 (2020-07-09)
Bile acids (BAs) play essential physiological roles not only by facilitating the absorption and transport of nutrients but also by acting as a complex molecular signaling system. Reduced levels of BAs have been observed in obesity and other metabolic disorders.
Ying Zhu et al.
The Journal of biological chemistry, 294(52), 19923-19933 (2019-11-17)
Plant development is regulated by both synergistic and antagonistic interactions of different phytohormones, including a complex crosstalk between ethylene and auxin. For instance, auxin and ethylene synergistically control primary root elongation and root hair formation. However, a lack of chemical
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3079-25MG | 04065266444599 |
| SML3079-5MG | 04065266444605 |