SML2998

Moxidectin

≥98% (HPLC)

• Synonym(s): Moxidectin, (6R,23E,25S)-5-O-Demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)milbemycin B, 23-Methoxime-LL-F 28249α, CL 301,423, CL 301423, CL301,423, CL301423, Equest, ProHeart 6
• Empirical Formula (Hill Notation): C₃₇H₅₃NO₈
• CAS Number: 113507-06-5
• Molecular Weight: 639.82
• UNSPSC Code: 12352119
• NACRES: NA.77
• MDL number: MFCD00866560
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CO\N=C1/C[C@]2(C[C@@H]3CC(C\C=C(C)\C[C@@H](C)\C=C\C=C4/COC5[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]45O)O2)O[C@@H]([C@H]1C)\C(C)=C\C(C)C
• InChI: 1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31+/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1
• InChI key: YZBLFMPOMVTDJY-LSGXYNIPSA-N

Description

Biochem/physiol Actions

Moxidectin is an orally active antihelminthic (antiparasitic) that targets parasite glutamate-gated chloride ion channels (GluCls). Moxidectin binding increases target GluCl permeability, resulting in influx of chloride ions and dysfunction of the excretory pore, flaccid paralysis, and death of the parasite through host response.

Safety Information

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301,H400
• pcodes: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3