They wouldn't tell me what the thing is dissolved in, preventing me from having the proper vehicle control for experimentation. Disappointing service.
SML2709
Sphingosine 1-phosphate
≥95% (TLC), liquid, Lipid second messenger
Synonym(s):
(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate, D-erythro-Sphingosine 1-phosphate, S1P
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| Size/SKU | Availability | Price |
|---|---|---|
0.1 mL | Please contact Customer Service for Availability | 2 960,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C18H38NO5P
Molecular Weight:
379.47
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (TLC)
Form:
liquid
Product Name
Sphingosine 1-phosphate ready made solution, ≥95% (TLC), Fully soluble 10mM solution
Quality Segment
assay
≥95% (TLC)
form
liquid
storage temp.
−20°C
General description
Sphingosine 1-phosphate (S1P) is a sphingolipid derived from ceramide by an enzymatic reaction in vivo.1 S1P acts as a signaling molecule by binding to G-protein coupled receptors (S1PR) (S1P1-5 receptors) which results in activation of small GTPases such as Ras, Rac Rho and further downstream intracellular effects such as PI-3-Kinase, Protein kinase C and Hippo signaling pathways. This generates an effect on cell migration, differentiation and survival and therefore effects variety of systems such as immune system, central nervous system and cardiovascular system.2 For instance, S1P was found to inhibit cell apoptosis and induce cell proliferation by binding S1P1 to promote activation of ERK pathway.3 In addition, S1P was found to support cancer cells by inducing angiogenesis and survival of proliferative cells in the tumor microenvironment.4 Due to the vast activities of S1P and the resulted S1PR irregular activation, large discovery efforts are made to identify therapy by S1PR antagonists.5
Biochem/physiol Actions
Anti angigoenesis
Other Notes
Sphingosine 1-phosphate ready made solution is supplied in aqueous solution at 10mM concentration and can be further diluted (X10000) to a working concentration of 1μM.
1 of 1
This Item | |||
|---|---|---|---|
| description ≥95% (TLC), Fully soluble 10mM solution | description ≥95%, powder | description ≥98.0% (TLC) | description A putative second messenger that mobilizes calcium from intracellular stores via an IP3-independent pathway. |
| assay ≥95% (TLC) | assay ≥95% | assay ≥98.0% (TLC) | assay ≥95% (elemental analysis) |
| form liquid | form powder | form powder | form solid |
| Quality Level 100 | Quality Level 300 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
109-89-7
CAS No.
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