SML2704

BAY-294

≥98% (HPLC)

• Synonym(s): BAY-294, 6,7-Dimethoxy-2-methyl-N-[(S)-1-(4-{2-[(methylamino)methyl]phenyl}thien-2-yl)ethyl]quinazolin-4-amine, BAY 293 (S)-enantiomer, BAY 293 control, BAY 294, BAY-293 (S)-enantiomer, BAY-293 control, BAY293 (S)-enantiomer, BAY293 control, BAY294
• Empirical Formula (Hill Notation): C₂₅H₂₈N₄O₂S
• CAS Number: 2244904-69-4
• Molecular Weight: 448.58
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +86.0 to +106.0°, c = 1.0 in DMSO
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: C[C@@H](C1=CC(C2=CC=CC=C2CNC)=CS1)NC3=C4C=C(C(OC)=CC4=NC(C)=N3)OC
• InChI: 1S/C25H28N4O2S/c1-15(24-10-18(14-32-24)19-9-7-6-8-17(19)13-26-3)27-25-20-11-22(30-4)23(31-5)12-21(20)28-16(2)29-25/h6-12,14-15,26H,13H2,1-5H3,(H,27,28,29)/t15-/m0/s1
• InChI key: WEGLOYDTDILXDA-HNNXBMFYSA-N

Description

Biochem/physiol Actions

BAY-294 corresponds to the (S)-enantiomer of and the recommended control for the selective SOS1-KRAS interaction inhibitor BAY-293 (IC50 = 2.34 μM/BAY-294 vs. 21 nM/BAY-293; 10 nM hSOS1cat & 5 nM hKRAS G12C). BAY-294 exhibits little potency against SOS1-mediated KRAS activation (IC50 = 3.91 μM/BAY-294 vs. 52 nM/BAY-293; 10 nM SOS1cat & 50 nM wt hKRAS).

Control (S)-enantiomer of the selective SOS1-KRAS interaction inhibitor BAY-293.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable