Skip to Content
Merck

Skip To

SML2699

SHMT inhibitor Hit 1

≥98% (HPLC)

Synonym(s):

4,4′-[2,4-Pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo-butanoic acid

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
CZK 2,450.00
25 mg
Please contact Customer Service for Availability
CZK 9,900.00
CZK 8,415.00

About This Item

Empirical Formula (Hill Notation):
C24H22N4O6
CAS Number:
Molecular Weight:
462.45
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

CZK 2,450.00


Please contact Customer Service for Availability

Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NC1=CC=C(C2=NC=CC(C3=CC=C(C=C3)NC(CCC(O)=O)=O)=N2)C=C1)CCC(O)=O

InChI

1S/C24H22N4O6/c29-20(9-11-22(31)32)26-17-5-1-15(2-6-17)19-13-14-25-24(28-19)16-3-7-18(8-4-16)27-21(30)10-12-23(33)34/h1-8,13-14H,9-12H2,(H,26,29)(H,27,30)(H,31,32)(H,33,34)

InChI key

LZRQXDAEFLBXCL-UHFFFAOYSA-N

Biochem/physiol Actions

Inhibition of serine/glycine synthesis by SHMT inhibitors can be an effective strategy to treat serine/glycine synthesis-dependent cancers.[1] Therefore, SHMT inhibitor can be a potential cancer drug target.[2] SHMT inhibitor Hit 1 may inhibit SHMT with an IC50 of 0.53 μM.[2]
SHMT inhibitor Hit 1 is a potent and specific inhibitor of serine hydroxymethyltransferase (SHMT). SHMT inhibitor Hit 1 potently inhibits SHMT1 and SHMT2 in rat liver homogenate.
potent and specific inhibitor of serine hydroxymethyltransferase (SHMT)

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SML0989SML0840SML2838
form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 25 mg/mL, clear

solubility

H2O: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

Reviews

No rating value

Active Filters