SML2683

dBET6

≥98% (HPLC)

• Synonym(s): (6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
• Empirical Formula (Hill Notation): C₄₂H₄₅ClN₈O₇S
• CAS Number: 1950634-92-0
• Molecular Weight: 841.37
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD31692407
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• ligand: thalidomide
• assay: ≥98% (HPLC)
• form: powder
• technique(s): targeted protein degradation: suitable
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [s]1c2c(c(c1C)C)C(=N[C@H](c7[n]2c(nn7)C)CC(=O)NCCCCCCCCNC(=O)COc4c5c(ccc4)C(=O)N(C5=O)C6CCC(=O)NC6=O)c3ccc(cc3)Cl
• InChI: 1S/C42H45ClN8O7S/c1-23-24(2)59-42-35(23)37(26-13-15-27(43)16-14-26)46-29(38-49-48-25(3)50(38)42)21-33(53)44-19-8-6-4-5-7-9-20-45-34(54)22-58-31-12-10-11-28-36(31)41(57)51(40(28)56)30-17-18-32(52)47-39(30)55/h10-16,29-30H,4-9,17-22H2,1-3H3,(H,44,53)(H,45,5
• InChI key: JGQPZPLJOBHHBK-UFXYQILXSA-N

Description

Biochem/physiol Actions

dBET6 is a highly cell penetrant, potent and selective BET (bromodomain and extra-terminal domain) degrader that induces rapid (<4hrs) degradation of BRD2, BRD3 and BRD4 and complete down-regulation of c-MYC protein and induction of apoptosis. dBET6 exhibits potent anti-cancer activities.

highly cell penetrant, potent and selective BETdegrader that induces rapid degradation of BRD2, BRD3 and BRD4

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable