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SML2662

SPA70

≥98% (HPLC), human pregnane X receptor antagonist, powder

Synonym(s):

1-(2,5-Dimethoxyphenyl)-4-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-5-methyl-1H-12,3-triazole, LC-1

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Size/SKUAvailabilityPrice
5 mg
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3 880,00 CZK
25 mg
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12 400,00 CZK

About This Item

Empirical Formula (Hill Notation):
C21H25N3O4S
CAS Number:
Molecular Weight:
415.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

3 880,00 CZK


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Product Name

SPA70, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(c2nn[n](c2C)c3c(ccc(c3)OC)OC)c1ccc(cc1)C(C)(C)C

InChI key

OIOPHIFJQXHPAF-UHFFFAOYSA-N

Biochem/physiol Actions

SPA70 is a cell penetrant, potent and highly selective human pregnane X receptor (hPXR) antagonist that inhibits hPXR in humanized mouse models. It inhibits hPXR-mediated drug metabolism in in primary human hepatocytes and in mouse models.
cell penetrant, potent and highly selective human pregnane X receptor (hPXR) antagonist that inhibits hPXR in humanized mouse models.


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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