SML2623

(+)-JQ-1 carboxylic acid

≥95% (HPLC)

• Synonym(s): (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, (S)-[4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-yl]acetic acid, 2-[(6S,Z)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid
• Empirical Formula (Hill Notation): C₁₉H₁₇ClN₄O₂S
• CAS Number: 202592-23-2
• Molecular Weight: 400.88
• UNSPSC Code: 12352106
• NACRES: NA.77
• MDL number: MFCD28167916
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [s]1c2c(c(c1C)C)C(=N[C@H](c4[n]2c(nn4)C)CC(=O)O)c3ccc(cc3)Cl
• InChI: 1S/C19H17ClN4O2S/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)21-14(8-15(25)26)18-23-22-11(3)24(18)19/h4-7,14H,8H2,1-3H3,(H,25,26)/t14-/m0/s1
• InChI key: LJOSBOOJFIRCSO-AWEZNQCLSA-N

Description

Biochem/physiol Actions

(+)-JQ-1 carboxylic acid is a potent BET (bromodomain and extra terminal domain) inhibitor. (+)-JQ-1 carboxylic acid could serve as precursor to synthesize PROTACs and other conjugates.

potent BET inhibitor; precursor to synthesize PROTACs

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable