SML2574
Candicidin
≥50% (HPLC)
Synonym(s):
Candicidin, Candeptin, Candimon, Levorin, Vanobid
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| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Please contact Customer Service for Availability | 3 210,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C59H84N2O18
CAS Number:
Molecular Weight:
1109.30
NACRES:
NA.77
UNSPSC Code:
51111800
Form:
solid
Storage condition:
protect from light
biological source
Streptomyces griseus
form
solid
storage condition
protect from light
concentration
≥50% (HPLC)
solubility
DMSO: 1 mg/mL
storage temp.
−20°C
General description
Candicidin is a polyene macrolide antifungal antibiotic which inhibits large number of fungi. 2 Polyene antifungal antibiotics, such as Candicidin, specifically target cell membranes containing sterols. Thus, selectively targets variety of prokaryotic organisms (such as Candida albicans) and not eukaryotic organisms. Candicidin generates cell membrane damage to Candida albicans (C.albicans) by triggering a rapid efflux of K+ ions. Interestingly, it was found that dosage needed for Candicidin to inhibit growth of stationary phase C. albicans cells is 25 μg/ml whereas log-phase C. albicans cells is only 5 μg/mL. In 1953 Kigman and Lewis performed the first in vivo study with mice to reveal the effects of Candicidin. Their study showed that Candicidin exhibits protective effect against C. albicans, Blastomyces dermatitidis and Sporotrichum schenkii but only a partial protective effect against torulosis and histoplasmosis. LD50 for Candicidin oral administration and intraperitoneal administration in mice were 90-400mg/kg and 2.1-7.0 mg/kg respectively. When comparing the activity of Candicidin to other antifungal compounds in vivo protects 100% of mice with C. albicans infection, whereas usage of twice the amount of Nystatin protects only 60% of the mice. Candicidin may undergo a photoisomerization process, yielding all-trans derivatives of Candicidin when exposed to direct UV light.
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This Item | |||
|---|---|---|---|
| description ≥50% (HPLC) | description phyproof® Reference Substance | description wire, diam. 1.0 mm, 99.995% trace metals basis | description foil, 4mm disks, thickness 0.125mm, as rolled, 100% |
| form solid | form - | form wire | form foil |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. - |
| solubility DMSO: 1 mg/mL | solubility - | solubility - | solubility - |
| storage condition protect from light | storage condition - | storage condition - | storage condition - |
| concentration ≥50% (HPLC) | concentration - | concentration - | concentration - |
| biological source Streptomyces griseus | biological source - | biological source - | biological source - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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