SML2534

DJ-V-159

≥98% (HPLC)

• Synonym(s): N1,N3-Bis(4-cyano-3-(trifluoromethyl)phenyl)isophthalamide, N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-1,3-Benzenedicarboxamide
• Empirical Formula (Hill Notation): C₂₄H₁₂F₆N₄O₂
• CAS Number: 2253744-53-3
• Molecular Weight: 502.37
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD31807620
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CC(C(NC2=CC=C(C#N)C(C(F)(F)F)=C2)=O)=CC=C1)NC3=CC(C(F)(F)F)=C(C#N)C=C3
• InChI key: VEVNLJLJLVESLL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

DJ-V-159 is an agonist of GPRC6A, a family C G protein coupled receptor proposed to be master regulator of energy metabolism. GPRC6A is the receptor for osteocalcin, basic amino acids (e.g., L-Arginine), cations (e.g., calcium), and is a membrane receptor for testosterone. DJ-V-159 activated GPRC6A at 0.2 nM concentrations and stimulated GPRC6A-mediated ERK phosphorylation and cAMP accumulation in GPRC6A expressing HEK-293 cells. DJ-V-159 was found to stimulate insulin secretion from mouse β-cells and and lower serum glucose in wild-type mice.

GPRC6A agonist found to stimulate insulin secretion from mouse β-cells and and lower serum glucose in wild-type mice

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable