SML2422

Sophocarpine

≥95% (HPLC)

• Synonym(s): (-)-Sophocarpine, 13,14-Didehydromatridin-15-one, SC
• Empirical Formula (Hill Notation): C₁₅H₂₂N₂O
• CAS Number: 6483-15-4
• Molecular Weight: 246.35
• UNSPSC Code: 12352200
• MDL number: MFCD00274555
• NACRES: NA.21
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• biological source: Sophora alopecuroides
• assay: ≥95% (HPLC)
• form: powder
• optical activity: [α]/D -26 to -35°, c = 0.5 in ethanol
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [Br-].N21[C@@H]3[C@@H]([C@@H]4N(C[C@@H]3CCC2)C(=O)C=CC4)CCC1.[H+]
• InChI: 1S/C15H22N2O.BrH/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14;/h1,7,11-13,15H,2-6,8-10H2;1H/t11-,12+,13+,15-;/m0./s1
• InChI key: NBBQEIQEBNYSFK-PUILLJIJSA-N

Description

Biochem/physiol Actions

Sophocarpine is a natural product found to have anti-inflammatory, anti-cancer, and antiviral activity. Sophocarpine was active in an mouse xenograft model. It inhibited growth of head and neck squamous cell carcinomas by downregulation of miR-21 expression. Sophocarpine was also shown to protecs mice from a form of hepatitis by inhibiting the IFNg/STAT1 pathway.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable