SML2410
ABC99
≥98% (HPLC)
Synonym(s):
7-(4-Chlorobenzyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 2,3-dihydro-4Hbenzo[b][1,4]oxazine-4-carboxylate
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 2 160,00 CZK |
25 mg | Please contact Customer Service for Availability | 9 640,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C22H21ClN4O5
CAS Number:
Molecular Weight:
456.88
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O=C(ON(C(N1C2CN(CC1)CC3=CC=C(C=C3)Cl)=O)C2=O)N4C5=CC=CC=C5OCC4
InChI key
OZPZCETZTBBQBO-UHFFFAOYSA-N
Biochem/physiol Actions
ABC99 is an N-hydroxyhydantoin (NHH) carbamate-based irreversible, potent and selective inhibitor against the serine hydrolase activity of the Wnt-deacylating enzyme NOTUM (IC50 = 13 nM against NOTUM-mediated labeling of fluorophosphonate (FP) probe), an enzyme that reverses the posttranslational O-linked palmitoleate modification of Wnt proteins. ABC99 prevents NOTUM-mediated negative regulation against Wnt3A-dependent cellular signaling (EC50 = 89 nM by HEK293T TOPflash reporter assay) with excellent selectivity over 65 other serine hydrolases, including PPT1.
Irreversible, potent and selective inhibitor against NOTUM serine hydrolase activity and sustanins Wnt3A-dependent signaling in the presence of NOTUM.
Inhibition of NOTUM has therapeutic use in treating degenerative diseases including osteopenia and osteoporosis.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description targeting mouse Notum | description from rabbit, purified by affinity chromatography |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - | assay - |
| form powder | form powder | form lyophilized powder | form - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. - |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 10 mg/mL, clear | solubility - | solubility - |
| color white to beige | color white to beige | color - | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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